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1

A common co-morbidity modulates disease expression and treatment efficacy in inherited cardiac sodium channelopathy

Rivaud, Mathilde R, Jansen, John A, Postema, Pieter G, Nannenberg, Eline A, Mizusawa, Yuka, van der Nagel, Roel, Wolswinkel, Rianne, van der Made, Ingeborg, Marchal, Gerard A, Rajamani, Sridharan, Bel

Journal:

European Heart Journal

Year:

2018

Language:

english

File:

PDF, 864 KB

english, 2018

2

Balance Between Rapid Delayed Rectifier K + Current and Late Na + Current on Ventricular Repolarization: An Effective Antiarrhythmic Target?

Hegyi, Bence, Chen-Izu, Ye, Izu, Leighton T., Rajamani, Sridharan, Belardinelli, Luiz, Bers, Donald M., BÃ¡nyÃ¡sz, TamÃ¡s

Journal:

Circulation Arrhythmia and Electrophysiology

Year:

2020

Language:

english

File:

PDF, 2.55 MB

english, 2020

3

[ASME ASME 2013 Gas Turbine India Conference - Bangalore, Karnataka, India (Thursday 5 December 2013)] ASME 2013 Gas Turbine India Conference - Cooling Efficiency Enhancement Using Impingement Cooling Technique for Turbine Blades

Rajamani, Keerthivasan, Ganesh, Madhu, Paramanandam, Karthikeyan, Jayamurugan, Chandiran, Narayanan, Sridharan R., Srinivasan, Balamurugan, Chandra, A.

Year:

2013

Language:

english

File:

PDF, 1.02 MB

english, 2013

4

If inhibition in the atrioventricular node by ivabradine causes rate-dependent slowing of conduction and reduces ventricular rate during atrial fibrillation

Verrier, Richard L., Bonatti, Rodolfo, Silva, Ana F.G., Batatinha, Julio A.P., Nearing, Bruce D., Liu, Gongxin, Rajamani, Sridharan, Zeng, Dewan, Belardinelli, Luiz

Journal:

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

5

Eleclazine, a new selective cardiac late sodium current inhibitor, confers concurrent protection against autonomically induced atrial premature beats, repolarization alternans and heterogeneity, and atrial fibrillation in an intact porcine model

Fuller, Henrique, Justo, Fernanda, Nearing, Bruce D., Kahlig, Kristopher M., Rajamani, Sridharan, Belardinelli, Luiz, Verrier, Richard L.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.74 MB

english, 2016

6

A Missense Variant in PLEC Increases Risk of Atrial Fibrillation

Thorolfsdottir, Rosa B., Sveinbjornsson, Gardar, Sulem, Patrick, Helgadottir, Anna, Gretarsdottir, Solveig, Benonisdottir, Stefania, Magnusdottir, Audur, Davidsson, Olafur B., Rajamani, Sridharan, Rod

Journal:

Journal of the American College of Cardiology

Year:

2017

Language:

english

File:

PDF, 1.90 MB

english, 2017

7

A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na + current

Yang, Pei-Chi, Song, Yejia, Giles, Wayne R., Horvath, Balazs, Chen-Izu, Ye, Belardinelli, Luiz, Rajamani, Sridharan, Clancy, Colleen E.

Journal:

The Journal of Physiology

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

8

A New Therapeutic Framework for Atrial Fibrillation Drug Development

Ang, Yen-Sin, Rajamani, Sridharan, Haldar, Saptarsi M., HÃ¼ser, JÃ¶rg

Journal:

Circulation Research

Year:

2020

File:

PDF, 2.46 MB

2020

9

Ranolazine Reduces Central Neuron Excitability by Slowly Interacting with NaV Channels

Hirakawa, Ryoko, Kahlig, Kristopher M., Shan, Mu, Liu, Lynda V., Shryock, John C., Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 41 KB

english, 2012

10

Antiepileptic activity of preferential inhibitors of persistent sodium current

Anderson, Lyndsey L., Thompson, Christopher H., Hawkins, Nicole A., Nath, Ravi D., Petersohn, Adam A., Rajamani, Sridharan, Bush, William S., Frankel, Wayne N., Vanoye, Carlos G., Kearney, Jennifer A.

Journal:

Year:

2014

Language:

english

File:

PDF, 933 KB

english, 2014

11

Overexpression of SCN5A in mouse heart mimics human syndrome of enhanced atrioventricular nodal conduction

Liu, Gong Xin, Remme, Carol Ann, Boukens, Bastiaan J., Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Year:

2015

Language:

english

File:

PDF, 2.93 MB

english, 2015

12

The novel late Na + current inhibitor, GS-6615 ( eleclazine ) and its anti-arrhythmic effects in rabbit isolated heart preparations

Rajamani, Sridharan, Liu, Gongxin, El-Bizri, Nesrine, Guo, Donglin, Li, Cindy, Chen, Xiao-Liang, Kahlig, Kris, Mollova, Nevena, Elzein, Elfatih, Zablocki, Jeff, Belardinelli, Luiz

Journal:

British Journal of Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

13

Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1.1 mutations

Kristopher M Kahlig, Irene Lepist, Kwan Leung, Sridharan Rajamani, Alfred L George

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 1006 KB

english, 2010

14

Simulated Block of Brain Na+ Channels by Ranolazine Predicts Selective Binding to Inactivated Conformations

Kahlig, Kris M., Liu, Lynda, Shryock, John C., Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 42 KB

english, 2012

15

Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

Ryoko Hirakawa, Nesrine El-Bizri, John C. Shryock, Luiz Belardinelli, Sridharan Rajamani

Journal:

Neuropharmacology

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

16

A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current

Yang, Pei-Chi, El-Bizri, Nesrine, Romero, Lucia, Giles, Wayne R., Rajamani, Sridharan, Belardinelli, Luiz, Clancy, Colleen E.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2016

Language:

english

File:

PDF, 1.88 MB

english, 2016

17

Genetic basis for the origin of cardiac arrhythmias: Implications for therapy

Mackenzi Mbai, Sridharan Rajamani, Brian P. Delisle, Blake D. Anson, Corey Anderson, Jonathan C. Makielski, Craig T. January

Journal:

Current Cardiology Reports

Year:

2002

Language:

english

File:

PDF, 290 KB

english, 2002

18

Selective Inhibition of Late Na+ Current Reduces Arrhythmic Activity in Spontaneously Hypertensive Rat Myocytes

El-Bizri, Nesrine, Nguyen, Steven, Liu, Gongxin, Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 85 KB

english, 2014

19

Unmasking atrial repolarization to assess alternans, spatiotemporal heterogeneity, and susceptibility to atrial fibrillation

Verrier, Richard L., Fuller, Henrique, Justo, Fernanda, Nearing, Bruce D., Rajamani, Sridharan, Belardinelli, Luiz

Journal:

Year:

2016

Language:

english

File:

PDF, 1.47 MB

english, 2016

20

Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+ Channels by Ranolazine

Rajamani, Sridharan, Shryock, John, Belardinelli, Luiz

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 56 KB

english, 2009

21

Use-dependent block of cardiac late Na+ current by ranolazine

Makielski, Jonathan C., Belardinelli, Luiz, Rajamani, Sridharan, El-Bizri, Nesrine, Shryock, John C.

Journal:

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

22

Selective Inhibition of the Late Sodium Current has No Adverse Effect on Electrophysiological or Contractile Function of the Normal Heart

Fernandes, Sarah, Hoyer, Kirsten, Liu, Gongxin, Wang, Wei-Qun, Dhalla, Arvinder K., Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Journal of Cardiovascular Pharmacology

Year:

2014

Language:

english

File:

PDF, 519 KB

english, 2014

23

SELECTIVE LATE INA INHIBITION BY GS967 EXERTS POTENT SUPPRESSION OF CATECHOLAMINE-INDUCED VENTRICULAR TACHYCARDIA

Bento, Afonso Alves, Bacic, Danilo, Carneiro, Juliana Saran, Nearing, Bruce, Rajamani, Sridharan, Belardinelli, Luiz, Verrier, Richard

Journal:

Journal of the American College of Cardiology

Year:

2015

Language:

english

File:

PDF, 411 KB

english, 2015

24

Selective Inhibition of Physiological Late Sodium Current Stabilizes Ventricular Repolarization

El-Bizri, Nesrine, Li, Cindy Hong, Liu, Gong-Xin, Rajamani, Sridharan, Belardinelli, Luiz

Journal:

American Journal of Physiology - Heart and Circulatory Physiology

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

25

Pro-arrhythmic effects of low plasma [K + ] in human ventricle: An illustrated review

Trenor, Beatriz, Cardona, Karen, Romero, Lucia, Gomez, Juan F., Saiz, Javier, Rajamani, Sridharan, Belardinelli, Luiz, Giles, Wayne

Journal:

Trends in Cardiovascular Medicine

Year:

2017

Language:

english

File:

PDF, 684 KB

english, 2017

26

Effect of ranolazine on ventricular repolarization in class III antiarrhythmic drug-treated rabbits

Frommeyer, Gerrit, Kaiser, Dennis, Uphaus, Timo, Kaese, Sven, Osada, Nani, Rajamani, Sridharan, Belardinelli, Luiz, Breithardt, Günter, Eckardt, Lars, Milberg, Peter

Journal:

Year:

2012

Language:

english

File:

PDF, 1.68 MB

english, 2012

27

Functional modulation of atrio-ventricular conduction by enhanced late sodium current and calcium-dependent mechanisms in Scn5a1798insD/+ mice

Rivaud, Mathilde R, Marchal, Gerard A, Wolswinkel, Rianne, Jansen, John A, van der Made, Ingeborg, Beekman, Leander, Ruiz-Villalba, AdriÃ¡n, Baartscheer, Antonius, Rajamani, Sridharan, Belardinelli, L

Journal:

Year:

2020

File:

PDF, 1.50 MB

2020

28

Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome

Lee L Eckhardt, Sridharan Rajamani, Craig T January

Journal:

British Journal of Pharmacology

Year:

2005

Language:

english

File:

PDF, 80 KB

english, 2005

29

New Insights into the Beneficial Electrophysiologic Profile of Ranolazine in Heart Failure: Prevention of Ventricular Fibrillation With Increased Postrepolarization Refractoriness and Without Drug-Induced Proarrhythmia

Gerrit Frommeyer, Sridharan Rajamani, Fabian Grundmann, Jörg Stypmann, Nani Osada, Günter Breithardt, Luiz Belardinelli, Lars Eckardt, Peter Milberg

Journal:

Journal of Cardiac Failure

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

30

In silico assessment of drug safety in human heart applied to late sodium current blockers

Trenor, Beatriz, Gomis-Tena, Julio, Cardona, Karen, Romero, Lucia, Rajamani, Sridharan, Belardinelli, Luiz, Giles, Wayne R, Saiz, Javier

Journal:

Year:

2013

Language:

english

File:

PDF, 3.71 MB

english, 2013

31

Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin

Kornyeyev, Dmytro, El-Bizri, Nesrine, Hirakawa, Ryoko, Nguyen, Steven, Viatchenko-Karpinski, Serge, Yao, Lina, Rajamani, Sridharan, Belardinelli, Luiz

Journal:

American Journal of Physiology - Heart and Circulatory Physiology

Year:

2016

Language:

english

File:

PDF, 476 KB

english, 2016

32

Combined Actions of Ivabradine and Ranolazine Reduce Ventricular Rate During Atrial Fibrillation

VERRIER, RICHARD L., SILVA, ANA F.G., BONATTI, RODOLFO, BATATINHA, JULIO A.P., NEARING, BRUCE D., LIU, GONGXIN, RAJAMANI, SRIDHARAN, ZENG, DEWAN, BELARDINELLI, LUIZ

Journal:

Journal of Cardiovascular Electrophysiology

Year:

2015

Language:

english

File:

PDF, 665 KB

english, 2015

33

Mechanism of the Preferential Block of the Atrial Sodium Current by Ranolazine

Zygmunt, Andrew C., Nesterenko, Vladislav V., Rajamani, Sridharan, Hu, Dan, Barajas-Martinez, Hector, Belardinelli, Luiz, Antzelevitch, Charles

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 43 KB

english, 2009

34

Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress

Belardinelli, Luiz, Giles, Wayne R., Rajamani, Sridharan, Karagueuzian, Hrayr S., Shryock, John C.

Journal:

Year:

2015

Language:

english

File:

PDF, 899 KB

english, 2015

35

Inhibition of the cardiac late sodium current with eleclazine protects against ischemia-induced vulnerability to atrial fibrillation and reduces atrial and ventricular repolarization abnormalities in the absence and presence of concurrent adrenergic stimulation

Justo, Fernanda, Fuller, Henrique, Nearing, Bruce D., Rajamani, Sridharan, Belardinelli, Luiz, Verrier, Richard L.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.29 MB

english, 2016

36

Inhibition of late Na + current, a novel target to improve diastolic function and electrical abnormalities in Dahl salt-sensitive rats

Chi, Liguo, Belardinelli, Luiz, Zeng, Aliya, Hirakawa, Ryoko, Rajamani, Sridharan, Ling, Haiyun, Dhalla, Arvinder K.

Journal:

American Journal of Physiology - Heart and Circulatory Physiology

Year:

2016

Language:

english

File:

PDF, 932 KB

english, 2016

37

Simulation and Mechanistic Investigation of the Arrhythmogenic Role of the Late Sodium Current in Human Heart Failure

Trenor, Beatriz, Cardona, Karen, Gomez, Juan F., Rajamani, Sridharan, Ferrero, Jose M., Belardinelli, Luiz, Saiz, Javier, Rota, Marcello

Journal:

Year:

2012

Language:

english

File:

PDF, 571 KB

english, 2012

38

THE LATE SODIUM CURRENT INHIBITOR ELECLAZINE SUPPRESSES ATRIAL PREMATURE BEATS AND ATRIAL FIBRILLATION IN AN INTACT PORCINE MODEL

Fuller, Henrique, Justo, Fernanda, Nearing, Bruce, Rajamani, Sridharan, Belardinelli, Luiz, Verrier, Richard

Journal:

Journal of the American College of Cardiology

Year:

2016

Language:

english

File:

PDF, 486 KB

english, 2016

39

Cardiotoxic effects of fenfluramine hydrochloride on isolated cardiac preparations and ventricular myocytes of guinea-pigs

Sridharan Rajamani, Christian Studenik, Rosa Lemmens-Gruber, Peter Heistracher

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 246 KB

english, 2000

40

Ranolazine block of human Na v 1.4 sodium channels and paramyotonia congenita mutants

El-Bizri, Nesrine, Kahlig, Kristopher M., Shyrock, John C., George, Jr., Alfred L., Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

41

SELECTIVE INHIBITION OF THE CARDIAC LATE SODIUM CURRENT WITH ELECLAZINE PROTECTS AGAINST ISCHEMIA-INDUCED ATRIAL FIBRILLATION AND VULNERABILITY TO VENTRICULAR ARRHYTHMIAS

Justo, Fernanda, Fuller, Henrique, Nearing, Bruce, Rajamani, Sridharan, Belardinelli, Luiz, Verrier, Richard

Journal:

Journal of the American College of Cardiology

Year:

2016

Language:

english

File:

PDF, 482 KB

english, 2016

42

Enhanced late sodium current underlies pro-arrhythmic intracellular sodium and calcium dysregulation in murine sodium channelopathy

Rivaud, Mathilde R., Baartscheer, Antonius, Verkerk, Arie O., Beekman, Leander, Rajamani, Sridharan, Belardinelli, Luiz, Bezzina, Connie R., Remme, Carol Ann

Journal:

International Journal of Cardiology

Year:

2018

Language:

english

File:

PDF, 2.18 MB

english, 2018

43

Specific serine proteases selectively damage KCNH2 (hERG1) potassium channels and I Kr

Rajamani, Sridharan, Anderson, Corey L., Valdivia, Carmen R., Eckhardt, Lee L., Foell, Jason D., Robertson, Gail A., Kamp, Timothy J., Makielski, Jonathan C., Anson, Blake D., January, Craig T.

Journal:

AJP Heart and Circulatory Physiology

Year:

2006

Language:

english

File:

PDF, 375 KB

english, 2006

44

Carbon monoxide effects on human ventricle action potential assessed by mathematical simulations

Trenor, Beatriz, Cardona, Karen, Saiz, Javier, Rajamani, Sridharan, Belardinelli, Luiz, Giles, Wayne R.

Journal:

Frontiers in Physiology

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

45

Ultra-rapid kinetic interactions of ranolazine with Herg K+ current

Sridharan Rajamani, John C. Shryock, Luiz Belardinelli

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 63 KB

english, 2007

46

Block of Na+ Currents and Suppression of Action Potentials in Cultured Hippocampal Neurons by Gs-458967

Hirakawa, Ryoko, Belardinelli, Luiz, Rajamani, Sridharan

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 41 KB

english, 2014

47

Rapid Kinetic Interactions of Ranolazine With HERG K+ Current

Rajamani, Sridharan, Shryock, John C, Belardinelli, Luiz

Journal:

Journal of Cardiovascular Pharmacology

Year:

2008

Language:

english

File:

PDF, 332 KB

english, 2008

48

Ranolazine Effects on NaV1.2 and Modulation by pH

Peters, Colin H., Rajamani, Sridharan, Ruben, Peter C.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 55 KB

english, 2012

49

Proton Modulation of Ranolazine Effects on Slow Inactivation in Sodium Channels

Peters, Colin H., Sokolov, Stanislav, Rajamani, Sridharan, Ruben, Peter C.

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 93 KB

english, 2013

50

Cocaine Blocks HERG, but Not KvLQT1+minK, Potassium Channels

Zhang, Shetuan, Rajamani, Sridharan, Chen, Yuenmu, Gong, Qiuming, Rong, Yajing, Zhou, Zhengfeng, Ruoho, Arnold, January, Craig T.

Journal:

Molecular Pharmacology

Year:

2001

Language:

english

File:

PDF, 181 KB

english, 2001

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